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HAS2 Antibody

Purified Mouse Monoclonal Antibody

  • E - HAS2 Antibody AO1765a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - HAS2 Antibody AO1765a
    Figure 1: Western blot analysis using HAS2 mAb against human HAS2 recombinant protein. (Expected MW is 37.5 kDa)
  • WB - HAS2 Antibody AO1765a
    Figure 2: Western blot analysis using HAS2 mouse mAb against NTERA-2 (1), HEK293 (2) cell lysate.
  • IF - HAS2 Antibody AO1765a
    Figure 3: Immunofluorescence analysis of HeLa cells using HAS2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
  • IHC - HAS2 Antibody AO1765a
    Figure 4: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using HAS2 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92819
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4E7
Isotype IgG1
Calculated MW 63.5kDa
Description Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
Immunogen Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 3037
Other Names Hyaluronan synthase 2,, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2, HAS2
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/100 - 1/500
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHAS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HAS2
Function Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Expressed in fibroblasts.
Research Areas
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1.Cancer Res. 2012 Jan 15;72(2):537-47.2.J Biol Chem. 2011 Sep 23;286(38):33632-40.

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$ 385.00
Cat# AO1765a
(40 western blots)
Availability: 7-10 days
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