|Application ||WB, IHC, FC, E|
|Description||The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.|
|Immunogen||Purified recombinant fragment of human T (AA: 257-309 ) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Brachyury protein, Protein T, T|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||T Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.|
|Tissue Location||Detected in testis, but not in other, normal tissues. Detected in lung tumors (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
1.Am J Surg Pathol. 2008 Apr;32(4):572-80. 2.J Clin Neurosci. 2011 Jan;18(1):96-9.
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