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MEF2C Antibody

Purified Mouse Monoclonal Antibody

  • E - MEF2C Antibody AO1786a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - MEF2C Antibody AO1786a
    Figure 1: Western blot analysis using MEF2C mAb against human MEF2C recombinant protein. (Expected MW is 40 kDa)
  • WB - MEF2C Antibody AO1786a
    Figure 2: Western blot analysis using MEF2C mAb against HEK293 (1) and MEF2C (AA: 1-125)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - MEF2C Antibody AO1786a
    Figure 3: Western blot analysis using MEF2C mouse mAb against NIH3T3 (1) and 3T3-L1 (2) cell lysate.
  • FC - MEF2C Antibody AO1786a
    Figure 4: Flow cytometric analysis of HeLa cells using MEF2C mouse mAb (green) and negative control (purple).
  • IHC - MEF2C Antibody AO1786a
    Figure 5: Immunohistochemical analysis of paraffin-embedded colon cancer tissues using MEF2C mouse mAb with DAB staining.
  • IHC - MEF2C Antibody AO1786a
    Figure 6: Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using MEF2C mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q06413
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 6H2G2
Isotype IgG1
Calculated MW 51.2kDa
Description This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.
Immunogen Purified recombinant fragment of human MEF2C (AA: 1-125) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 4208
Other Names Myocyte-specific enhancer factor 2C, MEF2C
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEF2C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEF2C
Function Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Cellular Location Nucleus.
Tissue Location Expressed in brain and skeletal muscle.
Research Areas
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1.PLoS One. 2011;6(11):e27165. 2.J Biol Chem. 2011 Aug 26;286(34):30071-86.

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$ 385.00
Cat# AO1786a
(40 western blots)
Availability: 7-10 days
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