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KLF1 Antibody

Purified Mouse Monoclonal Antibody

  • E - KLF1 Antibody AO1794a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - KLF1 Antibody AO1794a
    Figure 1: Western blot analysis using KLF1 mAb against human KLF1 recombinant protein. (Expected MW is 42.6 kDa)
  • FC - KLF1 Antibody AO1794a
    Figure 2: Flow cytometric analysis of HeLa cells using KLF1 mouse mAb (green) and negative control (red).
  • IHC - KLF1 Antibody AO1794a
    Figure 3: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using KLF1 mouse mAb with DAB staining.
  • IHC - KLF1 Antibody AO1794a
    Figure 4: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using KLF1 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13351
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1B6A3
Isotype IgG1
Calculated MW 38.2kDa
Description This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
Immunogen Purified recombinant fragment of human KLF1 (AA: 208-362) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 10661
Other Names Krueppel-like factor 1, Erythroid krueppel-like transcription factor, EKLF, KLF1, EKLF
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKLF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLF1
Synonyms EKLF
Function Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Cellular Location Nucleus. Note=Colocalizes with SUMO1 in nuclear speckles.
Tissue Location Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines
Research Areas
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This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects.


1. J Biol Chem. 2011 Jul 15;286(28):24819-27. 2. Nat Genet. 2010 Sep;42(9):742-4.

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$ 385.00
Cat# AO1794a
(40 western blots)
Availability: 7-10 days
Bulk Size
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