|Application ||WB, FC, E|
|Description||This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface.|
|Immunogen||Purified recombinant fragment of human CD24 (AA: 15-80) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24, CD24A|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD24 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. ; ;
1. Cancer Res. 2012 Nov 1;72(21):5600-12. 2. Stem Cell Rev. 2012 Sep;8(3):779-91.
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