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SOX10 Antibody

Purified Mouse Monoclonal Antibody

     
  • E - SOX10 Antibody AO1875a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - SOX10 Antibody AO1875a
    Figure 1: Western blot analysis using SOX10 mAb against human SOX10 recombinant protein. (Expected MW is 31.7 kDa)
  • WB - SOX10 Antibody AO1875a
    Figure 2: Western blot analysis using SOX10 mAb against HEK293 (1) and SOX10 (AA: 147-252)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - SOX10 Antibody AO1875a
    Figure 3: Flow cytometric analysis of HepG2 cells using SOX10 mouse mAb (green) and negative control (red).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P56693
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2E7B5
Isotype IgG1
Calculated MW 49.9kDa
Description This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
Immunogen Purified recombinant fragment of human SOX10 (AA: 147-252) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 6663
Other Names Transcription factor SOX-10, SOX10
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOX10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX10
Function Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity).
Cellular Location Cytoplasm. Nucleus.
Tissue Location Expressed in fetal brain and in adult brain, heart, small intestine and colon
Research Areas
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Background

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. ;

References

1. J Am Acad Dermatol. 2012 Oct;67(4):717-26. 2. J Neurooncol. 2006 Jan;76(2):115-27.

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$ 385.00
Cat# AO1875a
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