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MLXIPL Antibody

Purified Mouse Monoclonal Antibody

  • E - MLXIPL Antibody AO1877a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - MLXIPL Antibody AO1877a
    Figure 1: Western blot analysis using MLXIPL mAb against human MLXIPL recombinant protein. (Expected MW is 41 kDa)
  • WB - MLXIPL Antibody AO1877a
    Figure 2: Western blot analysis using MLXIPL mAb against HEK293 (1) and MLXIPL (AA: 18-143)-hIgGFc transfected HEK293 (2) cell lysate.
  • IF - MLXIPL Antibody AO1877a
    Figure 3: Immunofluorescence analysis of Hela cells using MLXIPL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NP71
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5D12D1
Isotype IgG1
Calculated MW 93.1kDa
Description This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.
Immunogen Purified recombinant fragment of human MLXIPL (AA: 18-143) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 51085
Other Names Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, bHLHd14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, WS-bHLH, Williams-Beuren syndrome chromosomal region 14 protein, MLXIPL, BHLHD14, MIO, WBSCR14
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMLXIPL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BHLHD14, MIO, WBSCR14
Function Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in liver, heart, kidney, cerebellum and intestinal tissues
Research Areas
Citations (0)

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This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. ;


1. Diabetes. 2012 Mar;61(3):574-85. 2. Biochim Biophys Acta. 2011 Dec;1811(12):1194-200.

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$ 385.00
Cat# AO1877a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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