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SMCP Antibody

Purified Mouse Monoclonal Antibody

  • E - SMCP Antibody AO1936a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - SMCP Antibody AO1936a
    Figure 1: Western blot analysis using SMCP mAb against human SMCP (AA: FULL(1-116)) recombinant protein. (Expected MW is 38.3 kDa)
  • WB - SMCP Antibody AO1936a
    Figure 2: Western blot analysis using SMCP mAb against HEK293 (1) and SMCP (AA: FULL(1-116))-hIgGFc transfected HEK293 (2) cell lysate.
  • IF - SMCP Antibody AO1936a
    Figure 4: Immunofluorescence analysis of Hela cells using SMCP mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Secondary antibody from Fisher (Cat#: 35503)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49901
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5C10D8
Isotype IgG2b
Calculated MW 12.8kDa
Description Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.
Immunogen Purified recombinant fragment of human SMCP (AA: FULL(1-116)) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 4184
Other Names Sperm mitochondrial-associated cysteine-rich protein, SMCP, MCS, MCSP
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSMCP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MCS, MCSP
Function Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).
Cellular Location Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis
Tissue Location Testis. Is selectively expressed in the spermatids of seminiferous tubules.
Research Areas
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The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. ; ;


1. Biol Reprod. 1999 Aug;61(2):428-35.2. Mol Cell Biol. 2002 May;22(9):3046-52.

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$ 385.00
Cat# AO1936a
(40 western blots)
Availability: 7-10 days
Bulk Size
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