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CASP-7 Antibody

Purified Mouse Monoclonal Antibody

  • E - CASP-7 Antibody AO1994a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - CASP-7 Antibody AO1994a
    Figure 1: Western blot analysis using CASP-7 mAb against human CASP-7 (AA: 29-198) recombinant protein. (Expected MW is 22.5 kDa)
  • WB - CASP-7 Antibody AO1994a
    Figure 2: Western blot analysis using CASP-7 mAb against HEK293 (1) and CASP-7 (AA: 29-198)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - CASP-7 Antibody AO1994a
    Figure 3: Western blot analysis using CASP-7 mouse mAb against Jurkat (1), HEK293 (2), MOLT4 (3), MCF-7 (4), PC-12 (5) cell lysate.
  • FC - CASP-7 Antibody AO1994a
    Figure 4: Flow cytometric analysis of MCF-7 cells using CASP-7 mouse mAb (green) and negative control (red).
  • IHC - CASP-7 Antibody AO1994a
    Figure 5: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CASP-7 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P55210
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4D10B2
Isotype IgG1
Calculated MW 34.3kDa
Description This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Immunogen Purified recombinant fragment of human CASP-7 (AA: 29-198) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 840
Other Names Caspase-7, CASP-7,, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3, ICE-LAP3, Caspase-7 subunit p20, Caspase-7 subunit p11, CASP7, MCH3
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCASP-7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP7
Synonyms MCH3
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain
Research Areas
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1. Lung Cancer. 2009 Jul;65(1):19-24.2. Genes Cells. 2008 Jun;13(6):609-21.

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$ 385.00
Cat# AO1994a
(40 western blots)
Availability: 7-10 days
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