|Application ||WB, IHC, E|
|Description||CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling.|
|Immunogen||Purified recombinant fragment of human CD38 (AA: Extra(43-300)) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide.|
|Other Names||ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 18.104.22.168, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 22.214.171.124, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10, CD38, CD38|
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD38 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.|
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Provided below are standard protocols that you may find useful for product applications.
1. Biochem Biophys Res Commun. 2013 Dec 6;442(1-2):51-5.2. Mol Biol (Mosk). 2012 Sep-Oct;46(5):786-91.
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