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CBX1 Antibody

Purified Mouse Monoclonal Antibody

  • E - CBX1 Antibody AO2063a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - CBX1 Antibody AO2063a

    Figure 2:Western blot analysis using CBX1 mAb against human CBX1 (AA: 1-185) recombinant protein. (Expected MW is 47.3 kDa)

  • WB - CBX1 Antibody AO2063a

    Figure 3:Western blot analysis using CBX1 mAb against HEK293 (1) and CBX1 (AA: 1-185)-hIgGFc transfected HEK293 (2) cell lysate.

  • IF - CBX1 Antibody AO2063a

    Figure 4:Immunofluorescence analysis of Hela cells using CBX1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

  • FC - CBX1 Antibody AO2063a

    Figure 5:Flow cytometric analysis of Hela cells using CBX1 mouse mAb (green) and negative control (red).

  • IHC - CBX1 Antibody AO2063a

    Figure 6:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CBX1 mouse mAb with DAB staining.

  • IHC - CBX1 Antibody AO2063a

    Figure 7:Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using CBX1 mouse mAb with DAB staining.

  • IHC - CBX1 Antibody AO2063a

    Figure 8:Immunohistochemical analysis of paraffin-embedded colon cancer tissues using CBX1 mouse mAb with DAB staining.

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P83916
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4D7B8
Isotype IgG1
Calculated MW 21.4kDa
Description This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Immunogen Purified recombinant fragment of human CBX1 (AA: 1-185) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 10951
Other Names Chromobox protein homolog 1, HP1Hsbeta, Heterochromatin protein 1 homolog beta, HP1 beta, Heterochromatin protein p25, M31, Modifier 1 protein, p25beta, CBX1, CBX
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCBX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX1
Synonyms CBX
Function Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Cellular Location Nucleus. Note=Unassociated with chromosomes during mitosis
Tissue Location Expressed in all adult and embryonic tissues.
Citations (0)

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1.Endocr Relat Cancer. 2010 May 18;17(2):455-67.2.Am J Pathol. 2011 Feb;178(2):672-8.

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$ 385.00
Cat# AO2063a
(40 western blots)
Availability: 7-10 days
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