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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PLCG2 Antibody   

PLCG2 Antibody

Purified Mouse Monoclonal Antibody

  • E - PLCG2 Antibody AO2065a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - PLCG2 Antibody AO2065a

    Figure 2:Western blot analysis using PLCG2 mAb against human PLCG2 (AA: 826-985) recombinant protein. (Expected MW is 44.6 kDa)

  • WB - PLCG2 Antibody AO2065a

    Figure 3:Western blot analysis using PLCG2 mAb against HEK293 (1) and PLCG2 (AA: 826-985)-hIgGFc transfected HEK293 (2) cell lysate.

  • IF - PLCG2 Antibody AO2065a

    Figure 4:Immunofluorescence analysis of MCF-7 cells using PLCG2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

  • FC - PLCG2 Antibody AO2065a

    Figure 5:Flow cytometric analysis of Hela cells using PLCG2 mouse mAb (green) and negative control (red).

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16885
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2D9E8
Isotype IgG1
Calculated MW 147.9kDa
Description The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.
Immunogen Purified recombinant fragment of human PLCG2 (AA: 826-985) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 5336
Other Names 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-2,, Phosphoinositide phospholipase C-gamma-2, Phospholipase C-IV, PLC-IV, Phospholipase C-gamma-2, PLC-gamma-2, PLCG2
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLCG2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLCG2
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Research Areas
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1.J Biol Chem. 2005 Nov 25;280(47):38923-31.2.World J Gastroenterol. 2003 Nov;9(11):2413-8.

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$ 385.00
Cat# AO2065a
(40 western blots)
Availability: 7-10 days
Bulk Size
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