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BMP2 Antibody

Purified Mouse Monoclonal Antibody

     
  • E - BMP2 Antibody AO2072a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - BMP2 Antibody AO2072a

    Figure 2:Western blot analysis using BMP2 mAb against human BMP2 (AA: 283-396) recombinant protein. (Expected MW is 38.7 kDa)

  • WB - BMP2 Antibody AO2072a

    Figure 3:Western blot analysis using BMP2 mAb against HEK293 (1) and BMP2 (AA: 283-396)-hIgGFc transfected HEK293 (2) cell lysate.

  • FC - BMP2 Antibody AO2072a

    Figure 4:Flow cytometric analysis of Hela cells using BMP2 mouse mAb (green) and negative control (red).

  • FC - BMP2 Antibody AO2072a

    Figure 5:Flow cytometric analysis of A549 cells using BMP2 mouse mAb (green) and negative control (red).

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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P12643
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 9E10D6
Isotype IgG1
Calculated MW 44.7kDa
Description The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation.
Immunogen Purified recombinant fragment of human BMP2 (AA: 283-396) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 650
Other Names Bone morphogenetic protein 2, BMP-2, Bone morphogenetic protein 2A, BMP-2A, BMP2, BMP2A
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBMP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMP2
Synonyms BMP2A
Function Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Cellular Location Secreted.
Tissue Location Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine
Research Areas
Citations (0)

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References

1.Tissue Eng Part A. 2013 Dec;19(23-24):2664-73.2.BMC Biol. 2012 Apr 30;10:37.

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$ 385.00
Cat# AO2072a
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