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CBX6 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95503 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 8D10A3 |
| Isotype | IgG1 |
| Calculated MW | 43.9kDa |
| Description | CBX6 (chromobox homolog 6) is a protein-coding gene. GO annotations related to this gene include single-stranded RNA binding. An important paralog of this gene is CBX8. |
| Immunogen | Purified recombinant fragment of human CBX6 (AA: 269-412) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 23466 |
|---|---|
| Other Names | Chromobox protein homolog 6, CBX6 |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CBX6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CBX6 |
|---|---|
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3- independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). |
| Cellular Location | Nucleus. Chromosome. Note=Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235} |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.J Biol Chem. 2011 Jan 7;286(1):521-9.
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$ 385.00
Cat# AO2075a
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