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THAP1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9NVV9 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2F1B4 |
| Isotype | IgG1 |
| Calculated MW | 24.9kDa |
| Description | The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Immunogen | Purified recombinant fragment of human THAP1 (AA: 1-213) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 55145 |
|---|---|
| Other Names | THAP domain-containing protein 1, THAP1 |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | THAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THAP1 |
|---|---|
| Function | DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum- withdrawal and TNF-induced apoptosis. |
| Cellular Location | Nucleus, nucleoplasm. Nucleus, PML body |
| Tissue Location | Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Mov Disord. 2014 Feb;29(2):278-80.2.Hum Mutat. 2011 Nov;32(11):1213-24.
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$ 385.00
Cat# AO2079a
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