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THAP1 Antibody

Purified Mouse Monoclonal Antibody

  • E - THAP1 Antibody AO2079a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - THAP1 Antibody AO2079a

    Figure 2:Western blot analysis using THAP1 mAb against human THAP1 (AA: 1-213) recombinant protein. (Expected MW is 50.3 kDa)

  • WB - THAP1 Antibody AO2079a

    Figure 3:Western blot analysis using THAP1 mAb against HEK293 (1) and THAP1 (AA: 1-213)-hIgGFc transfected HEK293 (2) cell lysate.

  • FC - THAP1 Antibody AO2079a

    Figure 4:Flow cytometric analysis of A549 cells using THAP1 mouse mAb (green) and negative control (red).

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NVV9
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2F1B4
Isotype IgG1
Calculated MW 24.9kDa
Description The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Immunogen Purified recombinant fragment of human THAP1 (AA: 1-213) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 55145
Other Names THAP domain-containing protein 1, THAP1
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTHAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THAP1
Function DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Cellular Location Nucleus, nucleoplasm. Nucleus, PML body
Tissue Location Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta
Research Areas
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1.Mov Disord. 2014 Feb;29(2):278-80.2.Hum Mutat. 2011 Nov;32(11):1213-24.

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$ 385.00
Cat# AO2079a
(40 western blots)
Availability: 7-10 days
Bulk Size
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