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TWIST2 Antibody

Purified Mouse Monoclonal Antibody

  • E - TWIST2 Antibody AO2204a

    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

  • WB - TWIST2 Antibody AO2204a

    Figure 2:Western blot analysis using TWIST2 mAb against human TWIST2 (AA: 1-160) recombinant protein. (Expected MW is 44.1 kDa)

  • WB - TWIST2 Antibody AO2204a

    Figure 3:Western blot analysis using TWIST2 mAb against HEK293 (1) and TWIST2 (AA: 1-160)-hIgGFc transfected HEK293 (2) cell lysate.

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WVJ9
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1A11D9
Isotype IgG1
Calculated MW 18.1kDa
Description The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found.
Immunogen Purified recombinant fragment of human TWIST2 (AA: 1-160) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 117581
Other Names Twist-related protein 2, Class A basic helix-loop-helix protein 39, bHLHa39, Dermis-expressed protein 1, Dermo-1, TWIST2, BHLHA39, DERMO1
Dilution E~~1/10000
WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTWIST2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BHLHA39, DERMO1
Function Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:11062344}. Cytoplasm. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues
Tissue Location In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules.
Research Areas
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1.World J Gastroenterol. 2013 Apr 21;19(15):2404-11.2.Oncotarget. 2011 Dec;2(12):1165-75.

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$ 385.00
Cat# AO2204a
(40 western blots)
Availability: 7-10 days
Bulk Size
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