|Application ||WB, FC, E|
|Description||This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.|
|Immunogen||Purified recombinant fragment of human TGFBR3 (AA: 147-328 ) expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Transforming growth factor beta receptor type 3, TGF-beta receptor type 3, TGFR-3, Betaglycan, Transforming growth factor beta receptor III, TGF-beta receptor type III, TGFBR3|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TGFBR3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.|
|Cellular Location||Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix|
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1.Mol Biol Cell. 2011 May;22(9):1463-72. 2.Zhongguo Fei Ai Za Zhi. 2010 May;13(5):451-7.
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