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ITGB4 Antibody

Purified Mouse Monoclonal Antibody

  • E - ITGB4 Antibody AO2304a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - ITGB4 Antibody AO2304a
    Figure 1: Western blot analysis using ITGB4 mAb against human ITGB4 recombinant protein. (Expected MW is 24 kDa)
  • WB - ITGB4 Antibody AO2304a
    Figure 2: Western blot analysis using ITGB4 mouse mAb against A549 (1), A431 (2), MCF-7 (3) and SW620 (4) cell lysate.
  • FC - ITGB4 Antibody AO2304a
    Figure 3: Flow cytometric analysis of A549 cells using ITGB4 mouse mAb (green) and negative control (purple).
  • IHC - ITGB4 Antibody AO2304a
    Figure 4: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using ITGB4 mouse mAb with DAB staining.
  • IHC - ITGB4 Antibody AO2304a
    Figure 5: Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using ITGB4 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16144
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 10B10D5
Isotype IgG1
Calculated MW 202kDa
Description Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Immunogen Purified recombinant fragment of human ITGB4 (AA: 1619-1822) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 3691
Other Names Integrin beta-4, GP150, CD104, ITGB4
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsITGB4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGB4
Function Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes
Tissue Location Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach
Research Areas
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1.PLoS One. 2012;7(4):e32060. 2.J Cell Biochem. 2010 Jun 1;110(3):718-24.

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$ 385.00
Cat# AO2304a
(40 western blots)
Availability: 7-10 days
Bulk Size
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