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> home > Products > Primary Antibodies > Antibody Collections > ER-Golgi transport > Mouse Monoclonal Antibody to Rab6b
Mouse Monoclonal Antibody to Rab6b
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q9NRW1 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6D12G9 |
| Isotype | Mouse IgG1 |
| Calculated MW | 23.5kDa |
| Description | RAB6B (RAB6B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB41.; |
| Immunogen | Purified recombinant fragment of human Rab6b (AA: 95-208) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 IHC: 1/200 - 1/1000 |
| Gene ID | 51560 |
|---|---|
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to Rab6b is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB6B (HGNC:14902) |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (Probable). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). |
| Cellular Location | Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum-Golgi intermediate compartment Cytoplasmic vesicle. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules |
| Tissue Location | Predominantly expressed in brain. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Exp Cell Res. 2007 Oct 1;313(16):3408-20. ; 2.J Cell Sci. 2000 Aug;113 ( Pt 15):2725-35.;
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$ 385.00
Cat# AO2354a
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