|Application ||WB, FC, ICC, E|
|Description||RBFOX3 (RNA Binding Protein, Fox-1 Homolog (C. Elegans) 3) is a Protein Coding gene. Diseases associated with RBFOX3 include vertebral artery occlusion and tuberculum sellae meningioma. Among its related pathways are Neuroscience. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBFOX1.;|
|Immunogen||Purified recombinant fragment of human RBFOX3 (AA: 1-140) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Application Note||ELISA: 1/10000|
WB: 1/500 - 1/2000
ICC: 1/200 - 1/1000
FCM: 1/200 - 1/400
|Other Names||FOX3; NEUN; FOX-3; HRNBP3|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Monoclonal Antibody to RBFOX3 is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).|
|Cellular Location||Nucleus. Cytoplasm. Note=Largely restricted to neuronal nuclei. However, significant cytoplasmic localization in neurons from brains from HIV-infected individuals with cognitive impairment.|
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Provided below are standard protocols that you may find useful for product applications.
1.Neurosci Lett. 2014 Jan 13;558:97-102. ; 2.PLoS One. 2013 Sep 6;8(9):e73323. ;
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