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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Mouse Monoclonal Antibody to IL1R1   

Mouse Monoclonal Antibody to IL1R1

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to IL1R1 AO2439a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • WB - Mouse Monoclonal Antibody to IL1R1 AO2439a
    Western blot analysis using IL1R1 mAb against human IL1R1 (AA: 18-167) recombinant protein. (Expected MW is 40.8 kDa)
  • WB - Mouse Monoclonal Antibody to IL1R1 AO2439a
    Western blot analysis using IL1R1 mAb against HEK293 (1) and IL1R1 (AA: 18-167)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - Mouse Monoclonal Antibody to IL1R1 AO2439a
    Western blot analysis using IL1R1 mouse mAb against Hela (1) cell lysate.
  • FC - Mouse Monoclonal Antibody to IL1R1 AO2439a
    Flow cytometric analysis of Hela cells using IL1R1 mouse mAb (green) and negative control (red).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P14778
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4D2D12
Isotype Mouse IgG1
Calculated MW 65.4kDa
Description This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12.;
Immunogen Purified recombinant fragment of human IL1R1 (AA: 18-167) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
FCM: 1/200 - 1/400
Additional Information
Gene ID 3554
Other Names P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to IL1R1 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL1R1
Synonyms IL1R, IL1RA, IL1RT1
Function Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).
Cellular Location Membrane; Single-pass type I membrane protein Cell membrane. Secreted
Tissue Location Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells
Research Areas
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References

1.PLoS One. 2015 Jun 22;10(6):e0131086. ; 2.Biochem Pharmacol. 2011 Nov 1;82(9):1153-62.;

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$ 385.00
Cat# AO2439a
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