|Application ||WB, FC, E|
|Description||This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12.;|
|Immunogen||Purified recombinant fragment of human IL1R1 (AA: 18-167) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Application Note||ELISA: 1/10000|
WB: 1/500 - 1/2000
FCM: 1/200 - 1/400
|Other Names||P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Monoclonal Antibody to IL1R1 is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IL1R, IL1RA, IL1RT1|
|Function||Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).|
|Cellular Location||Membrane; Single-pass type I membrane protein Cell membrane. Secreted|
|Tissue Location||Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells|
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Provided below are standard protocols that you may find useful for product applications.
1.PLoS One. 2015 Jun 22;10(6):e0131086. ; 2.Biochem Pharmacol. 2011 Nov 1;82(9):1153-62.;
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