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Mouse Monoclonal Antibody to ANAPC11
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NYG5 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6F1G9 |
| Isotype | Mouse IgG1 |
| Calculated MW | 9.8kDa |
| Description | ANAPC11 (Anaphase Promoting Complex Subunit 11) is a Protein Coding gene. Among its related pathways are Immune System and Cellular Senescence. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin-ubiquitin ligase activity.; |
| Immunogen | Purified recombinant fragment of human ANAPC11 (AA: 1-196) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 |
| Gene ID | 51529 |
|---|---|
| Other Names | APC11; Apc11p; HSPC214 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to ANAPC11 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ANAPC11 |
|---|---|
| Function | Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Genet Mol Res. 2012 Aug 24;11(3):2814-22. ; 2.Free Radic Biol Med. 2004 Aug 15;37(4):521-30.;
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$ 385.00
Cat# AO2459a
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