|Application ||WB, IHC-P, FC, E|
|Calculated MW||65054 Da|
|Antigen Region||522-550 aa|
|Other Names||PCNA-interacting partner, PARI, PARP-1 binding protein, PARP1-binding protein, PARPBP, PARPBP, C12orf48, PARI|
|Target/Specificity||This C12orf48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 522-550 amino acids from the C-terminal region of human C12orf48.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C12orf48 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect.|
|Cellular Location||Cytoplasm. Nucleus Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA|
|Tissue Location||Restricted to testis. Overexpressed in multiple cancer cells.|
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