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AEBP1 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP10098c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10098c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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AEBP1 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | Q8IUX7 |
| Other Accession | NP_001120.3 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 130929 Da |
AEBP1 Antibody (Center) - Additional info | |
| Gene ID 165 | |
| Other Names AEBP1; ACLP; Adipocyte enhancer-binding protein 1; Aortic carboxypeptidase-like protein | |
| Target/Specificity This AEBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-372 amino acids from the Central region of human AEBP1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AEBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AEBP1 Antibody (Center) - Protein Information | |
| Name AEBP1 | |
| Synonyms ACLP | |
| Function May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By similarity) | |
| Cellular Location Isoform 1: Secreted (By similarity). | |
| Tissue Location Expressed in osteoblast and visceral fat. | |
AEBP1 Antibody (Center) - Related products
AP10098c: AEBP1 Antibody (Center)
RI10158: AEBP1 predesign siRNA
AEBP1 Antibody (Center) - Application data
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AEBP1 Antibody (Center) (Cat. #AP10098c) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the AEBP1 antibody detected the AEBP1 protein (arrow).
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AEBP1 Antibody (Center) (Cat. #AP10098c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AEBP1 antibody detected the AEBP1 protein (arrow).
AEBP1 Antibody (Center) - Research Areas
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BACKGROUND
The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular smooth muscle cells.
REFERENCES
Majdalawieh, A., et al. Nucl Recept Signal 8, E004 (2010) : Schissel, S.L., et al. Am. J. Pathol. 174(3):818-828(2009) Zhang, L., et al. Mol. Med. 11 (1-12), 39-47 (2005) : Layne, M.D., et al. Mol. Cell. Biol. 21(15):5256-5261(2001) Muise, A.M., et al. Biochem. J. 343 PT 2, 341-345 (1999) :
