|Application ||WB, E|
|Calculated MW||120874 Da|
|Antigen Region||210-240 aa|
|Other Names||A disintegrin and metalloproteinase with thrombospondin motifs 10, ADAM-TS 10, ADAM-TS10, ADAMTS-10, 3424-, ADAMTS10|
|Target/Specificity||This ADAMTS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the N-terminal region of human ADAMTS10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADAMTS10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed in adult tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.
Morales, J., et al. Am. J. Hum. Genet. 85(5):558-568(2009)
Ben Yahia, S., et al. J. Hum. Genet. 54(9):550-553(2009)
Kutz, W.E., et al. Hum. Mutat. 29(12):1425-1434(2008)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Dagoneau, N., et al. Am. J. Hum. Genet. 75(5):801-806(2004)
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