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AMACR Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP10110b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10110b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
AMACR Antibody (C-term) - Product info | |
| Application | WB, IHC, FC, IF
|
| Primary Accession | Q9UHK6 |
| Other Accession | NP_976316.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 42387 Da |
AMACR Antibody (C-term) - Additional info | |
| Gene ID 23600 | |
| Other Names AMACR; Alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase | |
| Target/Specificity This AMACR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-359 amino acids from the C-terminal region of human AMACR. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 IF~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AMACR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AMACR Antibody (C-term) - Protein Information | |
| Name AMACR | |
| Function Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers | |
| Cellular Location Peroxisome. Mitochondrion. | |
AMACR Antibody (C-term) - Related products
AP10110b: AMACR Antibody (C-term)
RI10266: AMACR predesign siRNA
BP10110b: AMACR Antibody (C-term) Blocking peptide
AMACR Antibody (C-term) - Application data
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AMACR Antibody (C-term) (Cat. #AP10110b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the AMACR antibody detected the AMACR protein (arrow).
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AMACR antibody (C-term) (Cat. #AP10110b) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AMACR antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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AMACR Antibody (C-term) (Cat. #AP10110b) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Confocal immunofluorescent analysis of AMACR Antibody (C-term)(Cat. #AP10110b) with HepG2 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
AMACR Antibody (C-term) - Research Areas
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BACKGROUND
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.
REFERENCES
Murray, N.P., et al. Oncol. Rep. 24(3):687-692(2010) Sonwalkar, S.A., et al. Histopathology 56(7):900-907(2010) Lakis, S., et al. World J. Gastroenterol. 16(20):2476-2483(2010) Chen, W., et al. Mol. Biol. Rep. 36(3):423-430(2009) Mubiru, J.N., et al. Gene 327(1):89-98(2004)
