|Application ||WB, E|
|Other Accession||Q8BGU5, NP_659449.3, NP_859049.2|
|Calculated MW||39337 Da|
|Antigen Region||140-169 aa|
|Other Names||Cyclin-Y, Cyc-Y, Cyclin box protein 1, Cyclin fold protein 1, cyclin-X, CCNY, C10orf9, CBCP1, CFP1|
|Target/Specificity||This CCNY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-169 amino acids from the Central region of human CCNY.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCNY Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C10orf9, CBCP1, CFP1|
|Function||Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).
Wang, K., et al. Hum. Mol. Genet. 19(10):2059-2067(2010)
Xu, Y., et al. Oncol. Res. 18(8):359-364(2010)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Henckaerts, L., et al. Clin. Gastroenterol. Hepatol. 7(9):972-980(2009)
Jiang, M., et al. FEBS Lett. 583(13):2171-2178(2009)
If you have any additional inquiries please email technical services at firstname.lastname@example.org.