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CENPC1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CENPC1 Antibody (Center) AP10142c
    CENPC1 Antibody (Center) (Cat. #AP10142c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CENPC1 antibody detected the CENPC1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q03188
Other Accession NP_001803.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 106834 Da
Antigen Region 441-467 aa
Additional Information
Gene ID 1060
Other Names Centromere protein C, CENP-C, Centromere autoantigen C, Centromere protein C 1, CENP-C 1, Interphase centromere complex protein 7, CENPC, CENPC1, ICEN7
Target/Specificity This CENPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-467 amino acids from the Central region of human CENPC1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCENPC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CENPC1, ICEN7
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Cellular Location Nucleus. Chromosome, centromere, kinetochore Note=Localizes exclusively in the kinetochore domain of centromeres.
Citations (0)

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Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq].


Gopalakrishnan, S., et al. Hum. Mol. Genet. 18(17):3178-3193(2009) Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009) : Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009) Trazzi, S., et al. PLoS ONE 4 (6), E5832 (2009) : Seshadri, S., et al. BMC Med. Genet. 8 SUPPL 1, S15 (2007) :

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Cat# AP10142c
(40 western blots)
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