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AADAT Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP10161c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10161c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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AADAT Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | Q8N5Z0 |
| Other Accession | NP_872603.1, NP_057312.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 47352 Da |
AADAT Antibody (Center) - Additional info | |
| Gene ID 51166 | |
| Other Names AADAT; KAT2; Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II | |
| Target/Specificity This AADAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-232 amino acids from the Central region of human AADAT. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AADAT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AADAT Antibody (Center) - Protein Information | |
| Name AADAT | |
| Synonyms KAT2 | |
| Function Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) | |
| Cellular Location Mitochondrion (Potential). | |
| Tissue Location Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary | |
AADAT Antibody (Center) - Related products
AP10161c: AADAT Antibody (Center)
DC06203: Human AADAT cDNA Clone
AADAT Antibody (Center) - Application data
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AADAT Antibody (Center) (Cat. #AP10161c) western blot analysis in HepG2,Y79 cell line lysates (35ug/lane).This demonstrates the AADAT antibody detected the AADAT protein (arrow).
AADAT Antibody (Center) - Research Areas
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BACKGROUND
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.
REFERENCES
Han, Q., et al. Biosci. Rep. 28(4):205-215(2008) Rossi, F., et al. J. Biol. Chem. 283(6):3559-3566(2008) Han, Q., et al. J. Biol. Chem. 283(6):3567-3573(2008) Lamesch, P., et al. Genomics 89(3):307-315(2007) Goh, D.L., et al. Mol. Genet. Metab. 76(3):172-180(2002)
