|Application ||WB, E|
|Other Accession||NP_872603.1, NP_057312.1|
|Calculated MW||47352 Da|
|Antigen Region||196-224 aa|
|Other Names||Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, Alpha-aminoadipate aminotransferase, AadAT, Kynurenine aminotransferase II, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, Kynurenine--oxoglutarate transaminase II, AADAT, KAT2|
|Target/Specificity||This AADAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the Central region of human AADAT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AADAT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).|
|Tissue Location||Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.
Han, Q., et al. Biosci. Rep. 28(4):205-215(2008)
Rossi, F., et al. J. Biol. Chem. 283(6):3559-3566(2008)
Han, Q., et al. J. Biol. Chem. 283(6):3567-3573(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Goh, D.L., et al. Mol. Genet. Metab. 76(3):172-180(2002)
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