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>   home   >   Products   >   Primary Antibodies   >   ELL Antibody (C-term)   

ELL Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ELL Antibody (C-term) AP10171b
    ELL Antibody (C-term) (Cat. #AP10171b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the EKI2 antibody detected the EKI2 protein (arrow).
  • WB - ELL Antibody (C-term) AP10171b
    ELL Antibody (C-term) (Cat. #AP10171b) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the EKI2 antibody detected the EKI2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P55199
Other Accession NP_006523.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68265 Da
Antigen Region 516-545 aa
Additional Information
Gene ID 8178
Other Names RNA polymerase II elongation factor ELL, Eleven-nineteen lysine-rich leukemia protein, ELL, C19orf17
Target/Specificity This ELL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-545 amino acids from the C-terminal region of human ELL.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsELL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELL
Synonyms C19orf17
Function Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.
Cellular Location Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with EAF2 to nuclear speckles. Colocalizes with coilin in subnuclear cajal and histone locus bodies Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes
Tissue Location Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes
Citations (0)

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Liu, L., et al. Prostate 70(7):797-805(2010)
Zhou, J., et al. J. Biol. Chem. 284(28):19142-19152(2009)
Jiang, F., et al. Cancer Lett. 253(2):265-272(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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Cat# AP10171b
(40 western blots)
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