|Application ||WB, IHC-P, E|
|Other Accession||Q02195, P36363, NP_002000.1, P48808|
|Calculated MW||22509 Da|
|Antigen Region||57-86 aa|
|Other Names||Fibroblast growth factor 7, FGF-7, Heparin-binding growth factor 7, HBGF-7, Keratinocyte growth factor, FGF7, KGF|
|Target/Specificity||This FGF7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-86 amino acids from the Central region of human FGF7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGF7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.|
|Tissue Location||Epithelial cell.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
Lin, C.B., et al. J. Dermatol. Sci. 59(2):91-97(2010)
Bando, M., et al. Immunol. Cell Biol. 88(3):328-333(2010)
Wang, X., et al. Biomaterials 31(9):2542-2548(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Aguilar, S., et al. PLoS ONE 4 (11), E8013 (2009) :
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