|Application ||WB, E|
|Calculated MW||92850 Da|
|Antigen Region||111-138 aa|
|Other Names||P protein, Melanocyte-specific transporter protein, Pink-eyed dilution protein homolog, OCA2, D15S12, P|
|Target/Specificity||This OCA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the N-terminal region of human OCA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OCA2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.|
|Cellular Location||Melanosome membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the human homologue of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine - a precursor of melanin. Mutations in this gene result in type 2 oculocutaneous albinism. [provided by RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Mengel-From, J., et al. Forensic Sci Int Genet 4(5):323-328(2010)
Ibarrola-Villava, M., et al. Exp. Dermatol. 19(9):836-844(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :
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