|Application ||WB, IHC-P, E|
|Other Accession||Q5YLM1, Q6WQJ1, NP_006124.1|
|Calculated MW||114952 Da|
|Antigen Region||317-345 aa|
|Other Names||Sn1-specific diacylglycerol lipase alpha, DGL-alpha, 311-, Neural stem cell-derived dendrite regulator, DAGLA, C11orf11, KIAA0659, NSDDR|
|Target/Specificity||This DAGLA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-345 amino acids from the Central region of human DAGLA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DAGLA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C11orf11, KIAA0659, NSDDR|
|Function||Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highly expressed in brain and pancreas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.
Knight, M.A., et al. Hum. Mol. Genet. 17(24):3847-3853(2008)
Jung, K.M., et al. Mol. Pharmacol. 68(5):1196-1202(2005)
Bisogno, T., et al. J. Cell Biol. 163(3):463-468(2003)
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