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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > DAGLA Antibody (Center)
DAGLA Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9Y4D2 |
| Other Accession | Q5YLM1, Q6WQJ1, NP_006124.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 114952 Da |
| Antigen Region | 317-345 aa |
| Gene ID | 747 |
|---|---|
| Other Names | Sn1-specific diacylglycerol lipase alpha, DGL-alpha, 311-, Neural stem cell-derived dendrite regulator, DAGLA, C11orf11, KIAA0659, NSDDR |
| Target/Specificity | This DAGLA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-345 amino acids from the Central region of human DAGLA. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DAGLA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DAGLA |
|---|---|
| Synonyms | C11orf11, KIAA0659, NSDDR {ECO:0000303|R |
| Function | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2- arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:26668358, PubMed:23502535). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic density membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q6WQJ1}; Multi-pass membrane protein. Note=Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner |
| Tissue Location | Highly expressed in brain and pancreas. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.
References
Knight, M.A., et al. Hum. Mol. Genet. 17(24):3847-3853(2008)
Jung, K.M., et al. Mol. Pharmacol. 68(5):1196-1202(2005)
Bisogno, T., et al. J. Cell Biol. 163(3):463-468(2003)
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$ 365.00
$ 140.00
Cat# AP10260C
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