|Application ||WB, IHC-P, E|
|Other Accession||O08524, NP_478129.1|
|Calculated MW||36956 Da|
|Antigen Region||54-83 aa|
|Other Names||Beta-tectorin, TECTB|
|Target/Specificity||This TECTB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the N-terminal region of human TECTB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TECTB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The genes for alpha-tectorin (MIM 602574) and beta-tectorin encode the major noncollagenous proteins of the tectorial membrane of the cochlea.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Legan, P.K., et al. J. Biol. Chem. 272(13):8791-8801(1997)
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