PEAR1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q5VY43 |
Other Accession | NP_001073940.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 110666 Da |
Antigen Region | 961-990 aa |
Gene ID | 375033 |
---|---|
Other Names | Platelet endothelial aggregation receptor 1, hPEAR1, Multiple epidermal growth factor-like domains protein 12, Multiple EGF-like domains protein 12, PEAR1, MEGF12 |
Target/Specificity | This PEAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 961-990 amino acids from the C-terminal region of human PEAR1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PEAR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PEAR1 |
---|---|
Synonyms | MEGF12 |
Function | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). |
Cellular Location | Cell membrane; Single-pass membrane protein. Cell projection, lamellipodium. Note=Detected on the cell surface in resting platelets. |
Tissue Location | Expressed in umbilical vein endothelial cells and platelets (at protein level) (PubMed:15851471, PubMed:36792666) Expressed in coronary artery smooth muscle cells (at protein level) (PubMed:36792666). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion (PubMed:15851471). Expressed in umbilical artery endothelial cells, megakaryocytes, osteoblasts, coronary muscle and erythroid cells (PubMed:15851471). |
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Provided below are standard protocols that you may find useful for product applications.
Background
PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).
References
Johnson, A.D., et al. Nat. Genet. 42(7):608-613(2010)
Jones, C.I., et al. Blood 114(7):1405-1416(2009)
Herrera-Galeano, J.E., et al. Arterioscler. Thromb. Vasc. Biol. 28(8):1484-1490(2008)
Nanda, N., et al. J. Biol. Chem. 280(26):24680-24689(2005)
Nanda, N., et al. J. Biol. Chem. 280(26):24680-24689(2005)
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