|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8C0D5, NP_078856.4, NP_001035700.1|
|Calculated MW||125430 Da|
|Antigen Region||1062-1090 aa|
|Other Names||Elongation factor Tu GTP-binding domain-containing protein 1, Elongation factor-like 1, Protein FAM42A, EFTUD1, EFL1, FAM42A|
|Target/Specificity||This EFTUD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1090 amino acids from the C-terminal region of human EFTUD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EFTUD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.|
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Provided below are standard protocols that you may find useful for product applications.
Nicolas, E., et al. Eur. J. Hum. Genet. 18(10):1107-1113(2010)
Willer, C.J., et al. Nat. Genet. 41(1):25-34(2009)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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