|Application ||WB, IHC-P, E|
|Calculated MW||18280 Da|
|Antigen Region||8-37 aa|
|Other Names||AP-1 complex subunit sigma-3, Adaptor protein complex AP-1 subunit sigma-1C, Adaptor-related protein complex 1 subunit sigma-1C, Clathrin assembly protein complex 1 sigma-1C small chain, Golgi adaptor HA1/AP1 adaptin sigma-1C subunit, Sigma 1C subunit of AP-1 clathrin, Sigma-adaptin 1C, Sigma1C-adaptin, AP1S3|
|Target/Specificity||This AP1S3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human AP1S3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AP1S3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904).|
|Cellular Location||Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Rose, J. Phd, et al. Mol. Med. (2010) In press : Roeth, J.F., et al. J. Cell Biol. 167(5):903-913(2004) Hirst, J., et al. Mol. Biol. Cell 12(11):3573-3588(2001) Boehm, M., et al. Mol. Biol. Cell 12(10):2907-2920(2001) Kirchhausen, T. Nat. Rev. Mol. Cell Biol. 1(3):187-198(2000)
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