|Application ||WB, FC, E|
|Calculated MW||24690 Da|
|Antigen Region||1-30 aa|
|Other Names||Synaptonemal complex central element protein 2, Central element synaptonemal complex protein 1, SYCE2, CESC1|
|Target/Specificity||This SYCE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SYCE2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYCE2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).|
|Cellular Location||Nucleus. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE1 in the central elements (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Bolcun-Filas, E., et al. J. Cell Biol. 176(6):741-747(2007)
Costa, Y., et al. J. Cell. Sci. 118 (PT 12), 2755-2762 (2005) :
Grimwood, J., et al. Nature 428(6982):529-535(2004)
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