|Application ||WB, E|
|Other Accession||Q5PPI7, Q4KL25, NP_872354.1|
|Calculated MW||24201 Da|
|Antigen Region||186-214 aa|
|Other Names||Tetraspan membrane protein of hair cell stereocilia, Lipoma HMGIC fusion partner-like 5 protein, LHFPL5, TMHS|
|Target/Specificity||This LHFPL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-214 amino acids from the C-terminal region of human LHFPL5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LHFPL5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Efficient localization to the plasma membrane requires the presence of PCDH15.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis.
Cosetti, M., et al. Ann. Otol. Rhinol. Laryngol. 117(11):827-833(2008)
Shabbir, M.I., et al. J. Med. Genet. 43(8):634-640(2006)
Longo-Guess, C.M., et al. Proc. Natl. Acad. Sci. U.S.A. 102(22):7894-7899(2005)
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