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AIF1 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP10449a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10449a-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
AIF1 Antibody (N-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | P55008 |
| Other Accession | NP_001614.3 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 16703 Da |
AIF1 Antibody (N-term) - Additional info | |
| Gene ID 199 | |
| Other Names AIF1; G1; IBA1; Allograft inflammatory factor 1; Ionized calcium-binding adapter molecule 1; Protein G1 | |
| Target/Specificity This AIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-44 amino acids from the N-terminal region of human AIF1. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AIF1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AIF1 Antibody (N-term) - Protein Information | |
| Name AIF1 | |
| Synonyms G1, IBA1 | |
| Function Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1 Binds calcium. Plays a role in RAC signaling and in phagocytosis May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation | |
| Cellular Location Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis | |
| Tissue Location Detected in T-lymphocytes and peripheral blood mononuclear cells | |
AIF1 Antibody (N-term) - Related products
AP10449a: AIF1 Antibody (N-term)
AP11202b: AIF1 Antibody (C-term)
DC02667: Human AIF1 cDNA Clone
BP10449a: AIF1 Antibody (N-term) Blocking Peptide
AT1077a: AIF1 Antibody (monoclonal) (M01)
AF1039a: AIF1 / IBA1 (isoform 1 and 3) Antibody
AIF1 Antibody (N-term) - Application data
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AIF1 Antibody (N-term) (Cat. #AP10449a) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the AIF1 antibody detected the AIF1 protein (arrow).
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AIF1 antibody (N-term) (Cat. #AP10449a) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AIF1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
AIF1 Antibody (N-term) - Research Areas
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BACKGROUND
AIF1 is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma.
REFERENCES
Clancy, R.M., et al. Arthritis Rheum. 62(11):3415-3424(2010) Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010) Davila, S., et al. Genes Immun. 11(3):232-238(2010) Jia, J., et al. Pediatr. Res. 67(1):29-34(2010) Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
