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>   home   >   Products   >   Primary Antibodies   >   MCAF2 Antibody (Center)   

MCAF2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MCAF2 Antibody  (Center) AP10509c
    MCAF2 Antibody (Center) (Cat. #AP10509c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the MCAF2 antibody detected the MCAF2 protein (arrow).
  • WB - MCAF2 Antibody  (Center) AP10509c
    MCAF2 Antibody (Center) (Cat. #AP10509c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MCAF2 antibody detected the MCAF2 protein (arrow).
  • IHC-P - MCAF2 Antibody  (Center) AP10509c
    MCAF2 Antibody (Center) (Cat. #AP10509c) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MCAF2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - MCAF2 Antibody  (Center) AP10509c
    MCAF2 Antibody (Center) (Cat. #AP10509c) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession Q5U623
Other Accession NP_079273.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 75764 Da
Antigen Region 318-347 aa
Additional Information
Gene ID 80063
Other Names Activating transcription factor 7-interacting protein 2, ATF7-interacting protein 2, MBD1-containing chromatin-associated factor 2, ATF7IP2, MCAF2
Target/Specificity This MCAF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-347 amino acids from the Central region of human MCAF2.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMCAF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATF7IP2
Synonyms MCAF2
Function Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable).
Cellular Location Nucleus.
Citations (0)

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Background

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone 'Lys-9' trimethylation activity (Probable).

References

Adkins, D.E., et al. Mol. Psychiatry (2010) In press :
Ichimura, T., et al. J. Biol. Chem. 280(14):13928-13935(2005)

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$ 295.00
$ 99.00
Cat# AP10509c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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