|Application ||WB, E|
|Other Accession||NP_113661.2, NP_001137251.1, NP_054774.2|
|Calculated MW||79746 Da|
|Antigen Region||527-555 aa|
|Other Names||Intraflagellar transport protein 81 homolog, Carnitine deficiency-associated protein expressed in ventricle 1, CDV-1, IFT81, CDV1|
|Target/Specificity||This IFT81 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-555 amino acids from the C-terminal region of human IFT81.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IFT81 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region (PubMed:23990561). Required for ciliogenesis (PubMed:27666822, PubMed:23990561). Required for proper regulation of SHH signaling (PubMed:27666822).|
|Cellular Location||Cell projection, cilium|
|Tissue Location||Highly expressed in testis, moderately in ovary, heart, liver, skeletal muscle, kidney and pancreas, low in prostate, brain, placenta and lung and not detected in spleen, thymus, small intestine and colon. Isoform CDV-1R is abundantly expressed in testis.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Isoform CDV-1 may be involved in cardiac hypertrophy caused by carnitine deficiency (By similarity). Isoform CDV-1R appears to play a role in development of the testis and spermatogenesis (By similarity).
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Peng, J., et al. Mol. Biol. Rep. 29(4):353-362(2002)
Higashi, M., et al. Mamm. Genome 11(12):1053-1057(2000)
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