|Application ||WB, E|
|Other Accession||NP_001018099.1, NP_078887.2|
|Calculated MW||110011 Da|
|Antigen Region||26-54 aa|
|Other Names||Little elongation complex subunit 2, Interactor of little elongator complex ELL subunit 2, NMDA receptor-regulated protein 2, ICE2, BRCC1, NARG2|
|Target/Specificity||This NARG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human NARG2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NARG2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.|
|Cellular Location||Nucleus. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes|
|Tissue Location||Expressed at low levels in lung and testis.|
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Provided below are standard protocols that you may find useful for product applications.
NARG2 is expressed at relatively high levels in dividing and immature cells, and is down-regulated upon terminal differentiation. NARG2 is a novel (S/T)PXX motif-containing nuclear protein; this motif is present in many transcription factors as well as other regulatory proteins that bind to DNA such as histones and RNA polymerase II. Three different isoforms exist.
Sugiura, N., et al. Eur. J. Biochem. 271 (23-24), 4629-4637 (2004) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Sugiura, N., et al. J. Biol. Chem. 276(17):14257-14263(2001)
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