|Application ||IHC-P, WB, FC, E|
|Calculated MW||46850 Da|
|Antigen Region||58-87 aa|
|Other Names||HERV-H LTR-associating protein 2, Human endogenous retrovirus-H long terminal repeat-associating protein 2, HHLA2|
|Target/Specificity||This HHLA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-87 amino acids of human HHLA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HHLA2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B- cells, dendritic cells and macrophages. Not detected in T-cells|
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Mager, D.L., et al. Genomics 59(3):255-263(1999)
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