|Application ||WB, E|
|Calculated MW||140878 Da|
|Antigen Region||132-163 aa|
|Other Names||Fanconi anemia group J protein, Protein FACJ, ATP-dependent RNA helicase BRIP1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein C-terminal helicase 1, BRCA1-interacting protein 1, BRIP1, BACH1, FANCJ|
|Target/Specificity||This BRIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-163 amino acids from the N-terminal region of human BRIP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BRIP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.|
|Tissue Location||Ubiquitously expressed, with highest levels in testis.|
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Provided below are standard protocols that you may find useful for product applications.
BRIP1 is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1).
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Bailey, S.D., et al. Diabetes Care (2010) In press :
Solyom, S., et al. Fam. Cancer (2010) In press :
Xie, J., et al. Oncogene 29(17):2499-2508(2010)
Smith, I.M., et al. ORL J. Otorhinolaryngol. Relat. Spec. 72(1):44-50(2010)
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