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SREBF2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IF, IHC-P, E |
|---|---|
| Primary Accession | Q12772 |
| Other Accession | NP_004590.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 123688 Da |
| Antigen Region | 399-427 aa |
| Gene ID | 6721 |
|---|---|
| Other Names | Sterol regulatory element-binding protein 2, SREBP-2, Class D basic helix-loop-helix protein 2, bHLHd2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2, SREBF2, BHLHD2, SREBP2 |
| Target/Specificity | This SREBF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-427 amino acids from the Central region of human SREBF2. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SREBF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SREBF2 {ECO:0000303|PubMed:32322062, ECO:0000312|HGNC:HGNC:11290} |
|---|---|
| Function | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element- binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). |
| Cellular Location | [Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane; Multi- pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=At high sterol concentrations, the SCAP- SREBP is retained in the endoplasmic reticulum (PubMed:32322062). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:32322062). |
| Tissue Location | Ubiquitously expressed in adult and fetal tissues. |
Research Areas
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$ 385.00
Cat# AP10673C
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