|Application ||WB, FC, E|
|Other Accession||Q00756, NP_002702.2|
|Calculated MW||125767 Da|
|Antigen Region||754-782 aa|
|Other Names||Protein phosphatase 1 regulatory subunit 3A, Protein phosphatase 1 glycogen-associated regulatory subunit, Protein phosphatase type-1 glycogen targeting subunit, RG1, PPP1R3A, PP1G|
|Target/Specificity||This PPP1R3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-782 amino acids from the Central region of human PPP1R3A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPP1R3A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Skeletal muscle and heart.|
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Provided below are standard protocols that you may find useful for product applications.
The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. [provided by RefSeq].
Yoshida, T., et al. Int. J. Mol. Med. 24(2):233-246(2009)
Yoshida, T., et al. Genomics 93(3):221-226(2009)
Gieger, C., et al. PLoS Genet. 4 (11), E1000282 (2008) :
Savage, D.B., et al. PLoS Med. 5 (1), E27 (2008) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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