|Application ||WB, E|
|Calculated MW||42687 Da|
|Antigen Region||327-356 aa|
|Other Names||Neuropeptide S receptor, G-protein coupled receptor 154, G-protein coupled receptor PGR14, G-protein coupled receptor for asthma susceptibility, NPSR1, GPR154, GPRA, PGR14|
|Target/Specificity||This NPSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 327-356 amino acids from the C-terminal region of human NPSR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NPSR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR154, GPRA, PGR14|
|Function||G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.|
|Cellular Location||Isoform 1: Cell membrane; Multi- pass membrane protein Isoform 4: Cell membrane; Multi-pass membrane protein Isoform 5: Cytoplasm Isoform 7: Cytoplasm|
|Tissue Location||Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients|
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Provided below are standard protocols that you may find useful for product applications.
NPSR1 is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma.
Raczka, K.A., et al. Mol. Psychiatry 15 (11), 1045 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Donner, J., et al. Biol. Psychiatry 68(5):474-483(2010)
Domschke, K., et al. Mol. Psychiatry (2010) In press :
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
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