|Application ||WB, FC, IHC-P, E|
|Calculated MW||39731 Da|
|Antigen Region||118-145 aa|
|Other Names||Serum paraoxonase/arylesterase 1, PON 1, Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1, PON1, PON|
|Target/Specificity||This PON1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-145 amino acids from the Central region of human PON1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PON1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas|
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Provided below are standard protocols that you may find useful for product applications.
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.
Ergun, M.A., et al. Biochem. Genet. (2010) In press :
Cagirci, G., et al. J. Heart Valve Dis. 19(4):453-458(2010)
Mendonca, M.I., et al. Rev Port Cardiol 29(4):571-580(2010)
Hashemi, M., et al. Genet. Mol. Res. 9(3):1735-1741(2010)
Martinez, C., et al. BMC Neurol 10, 71 (2010) :
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