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WIBG Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP10709a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10709a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
WIBG Antibody (N-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q9BRP8 |
| Other Accession | Q8CHP5, A6QPH1, NP_115721.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 22656 Da |
WIBG Antibody (N-term) - Additional info | |
| Gene ID 84305 | |
| Other Names WIBG; PYM; Partner of Y14 and mago; Protein wibg homolog | |
| Target/Specificity This WIBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human WIBG. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions WIBG Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
WIBG Antibody (N-term) - Protein Information | |
| Name WIBG | |
| Synonyms PYM | |
| Function Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC | |
| Cellular Location Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and the cytoplasm Nuclear export is mediated by XPO1/CRM1 | |
WIBG Antibody (N-term) - Related products
AP10709a: WIBG Antibody (N-term)
WIBG Antibody (N-term) - Application data
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WIBG Antibody (N-term) (Cat. #AP10709a) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the WIBG antibody detected the WIBG protein (arrow).
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WIBG antibody (N-term) (Cat. #AP10709a) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervical tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the WIBG antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
WIBG Antibody (N-term) - Research Areas
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BACKGROUND
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
REFERENCES
Gehring, N.H., et al. Cell 137(3):536-548(2009) Diem, M.D., et al. Nat. Struct. Mol. Biol. 14(12):1173-1179(2007) Forler, D., et al. Nat. Biotechnol. 21(1):89-92(2003) Gatfield, D., et al. J. Cell Biol. 159(4):579-588(2002)
